Adenoma.com

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Cushing's disease and Cushing's syndrome - WebHealth

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In Cushing's disease the adrenal glands produce too much cortisol hormone, usually from a hormone producing adenoma in the adrenal gland. When cortisol is produced secondarily from ACTH stimulation by the pituitary gland or from a hypothalamic corticotropin releasing hormone producing tumor, the hyperactivity of the adrenal glands is called Cushing's syndrome. Typical symptoms are a moon face, thin skin texture, striae, elevated blood pressure, growth retardation, the pressence of an adrenal gland tumor, male pattern body hair growth and a male baldness pattern. In Cushing's syndrome a pituitary adenoma may be present. There is a danger of loss sight due to optic nerve damage. Diagnostic tests could include 24 hour urine cortisol tests, the dexamethasone suppression test, metyrapone test, ACTH stimulation test and the corticotropin hormone releasing stimulation test, to name a few. Imaging tests such as an MRI scan and others may be needed. Cushing's disease treatment has to address the underlying cause. In the case of a pituitary adenoma a transsphenoidal hypophysectomy would have to be done by an experienced neurosurgeon. In the case of an adrenal gland adenoma an adrenalectomy has to be done by a surgeon. An endocrinologist would have to overlook the time before, during and after surgery.

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